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生物学研究、细胞培养、转染、电泳、内毒素检测、生物鉴定、细胞相关等
℡ 4000-520-616
℡ 4000-520-616
Lonza/Human Renal Cells (Normal & Diseased)/CC-2553/1 Ea
产品编号:CC-2553
市  场 价:¥0.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:待定
品      牌: Lonza
公      司:Lonza
公司分类:
Lonza/Human Renal Cells (Normal & Diseased)/CC-2553/1 Ea
商品介绍

Renalproximaltubuleepithelialcellsstainedforγ-GTP

ProductOverview:

Lonza"sHumanRenalCellsincludecellsisolatedfromvariousnormalhumankidneytissuespecifictoeachcelltype. HumanRenalProximalTubuleCellsareisolatedfromtheproximaltubule.HumanRenalEpithelialCells(HRE)arecomprisedofcellsfromthecortexandglomerularregion.HumanRenalCorticalCells(HRCE)arefromproximalanddistaltubules.HumanMesangialCells(HMC)areisolatedfromtherenalglomerulusandmodifiedsmoothmusclecellsbetweencapillaries.   

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Renalepithelialcellsdisplayapolarizedmorphology,whichisessentialfortheirfunction.Theyreabsorbnearlyalloftheglucoseandaminoacidsintheglomerularfiltrate,whileallowingothersubstancesofnonutritionalvaluetobeexcretedintheurine.PhysiologicalprocesseslikeosmoregulationandexcretioncanbestudiedwithHREinvitro. Humanrenalepithelialcellsarealsocapableofinternalizingbacteriaandarelocatednearinjurysitesinavarietyofcongenital,metabolicandinflammatorydiseases.

 

Recommendedmedium:

  • RPTEC,HRE,HCREuse REGM™BulletKit™
  • NHMCuse MsGM™BulletKit™  

 

SelectReferenceswithLonza"sRenalCellsandMedia


  • Ischemiareperfusioninjury(IRI)causestissueandorganinjury,inpart,throughalterationsintissuebloodflowandtheproductionofreactiveoxygenspecies. Renaltubularepithelialcellsareatargetofcellinjury.ThesecellsundergoapoptoticdeathpostIRI.YaoM,RogersNM,CsányiG,RodriguezAI,RossMA,StCroixC,KnuppH,NovelliEM1,ThomsonAW5,PaganoPJ,IsenbergJS.Thrombospondin-1activationofsignal-regulatoryprotein-αstimulatesreactiveoxygenspeciesproductionandpromotesrenalischemiareperfusioninjury.JournaloftheAmericanSocietyofNephrology(2014);25(6):1171-1186
  • RenalPhysiology: Intercellularcommunicationisakeyprocessinthedevelopmentandmaintenanceofmulticellularorganisms.Studymentionedherereportedextensivespontaneousintercellularexchangeofcargovesiclesandorganellesbetweenprimaryhumanproximaltubularepithelialcells. SophieDomhan, LiliMa,AlbertTai,ZacharyAnaya,AfshinBeheshti,MartinZeier,LynnHlatky,AmirABDollahi.IntercellularCommunicationbyExchangeofCytoplasmicMaterialviaTunnelingNano-TubeLikeStructuresinPrimaryHumanRenalEpithelialCells.PLoSONE(2011);6(6):e21283
  • NephrotoxicityA studywasdonetoevaluatethedirecttoxicityofStreptozotocinonhumanrenalproximaltubuleepithelialcellswhichresultedinupregulationoftheactivatedformoftheendoplasmicreticulumstress(ERstress)intherenalepithelialcells.UetakeR,SakuraiT,KamiyoshiA,Ichikawa-ShindoY,KawateH,IesatoY,YoshizawaT,KoyamaT,YangL,ToriyamaY,YamauchiA,IgarashiK,TanakaM,KuwabaraT,MoriK,YanagitaM,MukoyamaM,ShindoT.Adrenomedullin-RAMP2systemsuppressesERstress-inducedtubulecelldeathandisinvolvedinkidneyprotection.PLoSONE(2014);9(2):e87667
  • RenalDrugTransporters: StudywasdoneusingLonza’shumanrenalproximaltubulecells(CC-2553),wheretheeffectofCobicistat(COBI)onthecytotoxicityof Tenofovir(TFV)inrenalcellcultureswasexaminedtoelucidaterenaldrug-druginteractionbetweenthesetwocomponents. KirstenM.Stray,RujutaA.Bam,GabrielBirkus,JiaHao,Eve-IreneLepist,StephenR.Yant,AdrianS.Ray,TomasCihlar. Evaluationoftheeffectofcobicistatontheinvitrorenaltransportandcytotoxicitypotentialoftenofovir.AntimicrobialAgentsandChemotherapy(2013);57(10):4982-4989
  • DiabeticNephropathy isachronic,progressiverenaldisease/diabetickidneydiseasethatdevelopsinapproximatelyonethirdofpeoplewithdiabetes. Inastudy,Lonza’shumanproximaltubularepithelialcellswereculturedinrespectivemedia(REGM).ThegroupinvestigatedtheroleofKLK1(kallikrein)intubularpro-inflammatoryresponsesinculturedhumanRPTECandexaminedtheroleofPAR-4(Protease-ActivatedReceptor4)activationinKLK1-mediatedsignalinginthedevelopmentofDN. YiuWH,WongDW,ChanLY,LeungJC,ChanKW,LanHY,LaiKN,TangSC.TissueKallikreinMediatesPro-InflammatoryPathwaysandActivationofProtease-ActivatedReceptor-4inProximalTubularEpithelialCells.PLoSONE(2014);9(2):e88894
  • Inanotherstudy,theroleofmicroRNA1207-5PintheimplicationofDiabeticnephropathywasshown,whereLonza’sMesangialcellsandnormalhumanrenalproximaltubuleepithelialcellswereused.M.LucreciaAlvarez,MahdiehKhosroheidari,ElenaEddy,JeffKiefer.RoleofMicroRNA1207-5PandItsHostGene,theLongNon-CodingRNAPvt1,asMediatorsofExtracellularMatrixAccumulationintheKidney:ImplicationsforDiabeticNephropathy.PLoSONE(2013);8(10):e77468

 

RelatedProducts: HumanHepatocytes


品牌介绍

龙沙生物技术有限公司于2019年05月10日成立。法定代表人David Johann Wach,公司经营范围包括:生物技术开发服务(我国稀有和特有的珍贵优良品种,国家保护的原产于我国的野生动、植物资源开发除外);生物技术推广服务(我国稀有和特有的珍贵优良品种,国家保护的原产于我国的野生动、植物资源开发除外);生物技术咨询、交流服务(我国稀有和特有的珍贵优良品种,国家保护的原产于我国的野生动、植物资源开发除外);生物技术转让服务(我国稀有和特有的珍贵优良品种,国家保护的原产于我国的野生动、植物资源开发除外);医学研究和试验发展(人体干细胞、基因诊断与治疗技术除外);药品研发(人体干细胞、基因诊断与治疗技术除外);货物进出口(涉及外资准入特别管理规定和许可审批的商品除外);技术进出口;贸易代理;商品批发贸易(涉及外资准入特别管理规定和许可审批的商品除外);生物药品制造;化学药品原料药制造;化学药品制剂制造等。

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